Antisettici e controllo della carica batterica nelle ulcere venose/Antiseptics and control of bacterial load in venous ulcers

  • Giuseppe Nebbioso | giuseppe.nebbioso@gmail.com ASL NA1 Centro, Ambulatorio di Riparazione Tissutale, Napoli, Italia.
  • Ciro Falasconi ASL NA1 Centro, Ambulatorio di Riparazione Tissutale, Napoli, Italia.
  • Viviana Nebbioso Facoltà di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Napoli "Federico II", Napoli, Italia.
  • Francesco Petrella ASL NA3 Sud, Ambulatorio di Riparazione Tissutale, Napoli, Italia.

Abstract

L’insorgenza di infezione su una lesione cutanea cronica determina un arresto del processo di riparazione tessutale e impone l’instaurazione di una terapia antibiotica sistemica che, in una fase iniziale, sarà empirica e, dunque, non scevra di insuccessi. L’utilizzo di antimicrobici con ridotto potere citotossoco/istiolesivo può essere considerata, in molti casi, una valida alternativa per il controllo della carica batterica e dell’infezione locale. L’associazione di antimicrobici a base di poliesanide biguanide, betaina e cadexomero iodico, in molti casi, permette di controllare/ridurre la carica batterica e l’infezione locale fungendo da starter per la ripresa del processo di riparazione tessutale.

The onset of infection on a skin ulcer (chronic wound) leads to a halt in the tissue repair process and requires a systemic antibiotic therapy which, at an early stage, will be empirical and, therefore, not free from setbacks. The use of antimicrobials with reduced cytotoxic/histiolesive power can be considered, in many cases, a valid alternative for bacterial burden and local infection control. The combination of antimicrobials based on polystyrene biguanide, betaine and iodine cadexomer, in many cases, allows to control/reduce the bacterial burden and local infection by acting as a starter for the resumption of the tissue repair process.

Dimensions

Altmetric

PlumX Metrics

Downloads

I dati di download non sono ancora disponibili

Riferimenti bibliografici

Nehal Gamal Hashem, Levita Hidayat, Leonard Berkowitz, Veena Venugopalan. Management of skin and soft-tissue infections at a community teaching hospital using a severity-of-illness tool.Journal of Antimicrobial Chemotherapy, Volume 71, Issue 11, 1 November 2016

Principi di best practice. Linee guida internazionali. III Congresso WUWH Toronto 2008

Sue E. Gardner, Stephen L. Hillis, Rita A. Frantz.Clinical Signs of Infection in Diabetic Foot Ulcers With High Microbial Load. Biological Research of Nursing January 14, 2009

Browne AC1, Vearncombe M, Sibbald RG. High bacterial load in asymptomatic diabetic patients with neurotrophic ulcers retards wound healing after application of Dermagraft. Ostomy Wound Manage. 2001 Oct;47(10):44-9.

Metcalf DG, Bowler PG, Hurlow J. A clinical algorithm for wound biofilm identification. J Wound Care 2014; 23(3):137–2

Rondas A.A., Schols JM,.Definition of infection in chronic wounds by Dutch nursing home physicians.Int. Wound J 2009; 6:267-74

Block SS. Definition of terms. In: Block SS, ed. Disinfection, Sterilization, and Preservation. Philadelphia: Lippincott Williams & Wilkins, 2001; 19- 28

Bellingeri A et al. Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic Wounds: a single-blind RCT. J Wound Care 2016; 25: 3, 160–168.

Hancock RE, Sahl HG. Antimicrobial and host-defense peptides as new antiinfective therapeutic strategies. Nat Biotechnol. 2006 Dec;24(12):1551-7

Michael J. Allen,3 Graham F. White and Andrew P. Morby The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide Microbiology (2006), 152, 989 – 1000

T. Bjarnsholt, R.Cooper et al. Gestione del Biofilm Documento di posizionamento WUWHS 2016 Wounds Ed.

Drosou A, Falabella A, Kirsner R.S. Antiseptics on Wounds: An Area of Controversy, Phillips, P. L. et al., Effects of Antimicrobial Agents on an (in-vitro) Biofilm Model of Wounds, 2003; 15 (5): 149-166.

Skin Wounds. Advances in wound care (2010) 1: 299-304.

Pubblicato
2018-06-22
Info
Fascicolo
Sezione
Articoli
Parole chiave:
Antisettici, Wound Care, Ulcere venose
##article.stats##
  • Abstract views: 666

  • PDF: 665
Come citare
Nebbioso, G., Falasconi, C., Nebbioso, V., & Petrella, F. (2018). Antisettici e controllo della carica batterica nelle ulcere venose/Antiseptics and control of bacterial load in venous ulcers. Italian Journal of Wound Care, 2(2). https://doi.org/10.4081/ijwc.2018.21